SMOKING AND BUERGER’S DISEASE: FROM HYPOTHESES TO EVIDENCE SYNTHESIS

Early after the definition of thromboangiitis obliterans (TAO), it was noticed that TAO patients are almost always tobacco smokers. Later on, relationship between continued smoking and prognosis documented. Consequently, came to be considered as main cause TAO. However, is still unknown why, amongst millions smokers, only a small number develop It also remains who continue smoking, half them show aggravation undergo amputations. The aims this review investigate evidence in support or against according TAO-related literature published from 1908 January 2022, discover possible role pathophysiology. Taken together, appears predisposes toward potential harmful effects aetiology helps vascular lesions. Therefore, cessation would helpful for improving reducing disease manifestation. concluding not open new door finding true discovering appropriate treatment medical management fail stop smoking.